Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.

ABSTRACT:

Background and purpose

Hyperdynamic circulation and mesenteric hyperaemia are found in cirrhosis. To delineate the role of endocannabinoids in these changes, we examined the cardiovascular effects of anandamide, AM251 (CB(1) antagonist), AM630 (CB(2) antagonist) and capsazepine (VR1 antagonist), in a rat model of cirrhosis.

Experimental approach

Cirrhosis was induced by bile duct ligation. Controls underwent sham operation. Four weeks later, diameters of mesenteric arteriole and venule (intravital microscopy), arterial pressure, cardiac output, systemic vascular resistance and superior mesenteric artery (SMA) flow were measured after anandamide, AM251 (with or without anandamide), AM630 and capsazepine administration. CB(1), CB(2) and VR1 receptor expression in SMA was asses

SUBMITTER: Moezi L 

PROVIDER: S-EPMC2014695 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature