Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock.

ABSTRACT: We have conducted longitudinal studies focused on the expression profiles of signaling pathways and gene networks in children with septic shock. Genome-level expression profiles were generated from whole blood-derived RNA of children with septic shock (n=30) corresponding to day one and day three of septic shock, respectively. Based on sequential statistical and expression filters, day one and day three of septic shock were characterized by differential regulation of 2,142 and 2,504 gene probes, respectively, relative to controls (n=15). Venn analysis demonstrated 239 unique genes in the day one dataset, 598 unique genes in the day three dataset, and 1,906 genes common to both datasets. Functional analyses demonstrated time-dependent, differential regulation of genes involved in multiple s

SUBMITTER: Shanley TP 

PROVIDER: S-EPMC2014731 | biostudies-literature | 2007 Sep-Oct

REPOSITORIES: biostudies-literature