Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection.

ABSTRACT: Despite the importance of vaccinia virus in basic and applied immunology, our knowledge of the human immune response directed against this virus is very limited. CD4(+) T cell responses are an important component of immunity induced by current vaccinia-based vaccines, and likely will be required for new subunit vaccine approaches, but to date vaccinia-specific CD4(+) T cell responses have been poorly characterized, and CD4(+) T cell epitopes have been reported only recently. Classical approaches used to identify T cell epitopes are not practical for large genomes like vaccinia. We developed and validated a highly efficient computational approach that combines prediction of class II MHC-peptide binding activity with prediction of antigen processing and presentation. Using this approach and

SUBMITTER: Calvo-Calle JM 

PROVIDER: S-EPMC2014795 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature