Early activation of quorum sensing in Pseudomonas aeruginosa reveals the architecture of a complex regulon.

ABSTRACT:

Background

Quorum-sensing regulation of gene expression in Pseudomonas aeruginosa is complex. Two interconnected acyl-homoserine lactone (acyl-HSL) signal-receptor pairs, 3-oxo-dodecanoyl-HSL-LasR and butanoyl-HSL-RhlR, regulate more than 300 genes. The induction of most of the genes is delayed during growth of P. aeruginosa in complex medium, cannot be advanced by addition of exogenous signal, and requires additional regulatory components. Many of these late genes can be induced by addition of signals early by using specific media conditions. While several factors super-regulate the quorum receptors, others may co-regulate target promoters or may affect expression posttranscriptionally.

Results

To better understand the contributions of super-regulation and co-regulation to

SUBMITTER: Schuster M 

PROVIDER: S-EPMC2018727 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature