GntR family of regulators in Mycobacterium smegmatis: a sequence and structure based characterization.

ABSTRACT:

Background

Mycobacterium smegmatis is fast growing non-pathogenic mycobacteria. This organism has been widely used as a model organism to study the biology of other virulent and extremely slow growing species like Mycobacterium tuberculosis. Based on the homology of the N-terminal DNA binding domain, the recently sequenced genome of M. smegmatis has been shown to possess several putative GntR regulators. A striking characteristic feature of this family of regulators is that they possess a conserved N-terminal DNA binding domain and a diverse C-terminal domain involved in the effector binding and/or oligomerization. Since the physiological role of these regulators is critically dependent upon effector binding and operator sites, we have analysed and classified these regulators into

SUBMITTER: Vindal V 

PROVIDER: S-EPMC2018728 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature