Airway strain during mechanical ventilation in an intact animal model.

ABSTRACT:

Rationale

Mechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).

Objectives

To measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.

Methods

Sprague-Dawley rats were anesthetized and mechanically ventilated with tidal volumes of 6, 12, and 25 cm(3)/kg with and without 10-cm H(2)O PEEP. Real-time tantalum bronchograms were obtained for each condition, using microfocal X-ray imaging. Images were used to calculate circumferential and longitudinal airway strains, and on the basis of a simplified ma

SUBMITTER: Sinclair SE 

PROVIDER: S-EPMC2020825 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature