Identification of gene markers for formaldehyde exposure in humans.

ABSTRACT:

Background

Formaldehyde (FA) is classified as a human carcinogen and has been linked to increased leukemia rates in some epidemiologic studies. Inhalation of FA induces sensory irritation at relatively low concentrations. However, little is known concerning the cellular alterations observed after FA exposure in humans.

Objectives

Our aim was to profile global gene expression in Hs 680.Tr human tracheal fibroblasts exposed to FA and to develop biomarkers for the evaluation of FA exposure in humans.

Methods and results

We used gene expression analysis, and identified 54 genes designated as FA responsive. On the basis of these data, we conducted an exploratory analysis of the expression of these genes in human subjects exposed to high or low levels of FA. We monitored FA

SUBMITTER: Li GY 

PROVIDER: S-EPMC2022670 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature