Experimental transmission of atypical scrapie to sheep.

ABSTRACT:

Background

Active surveillance for transmissible spongiform encephalopathies in small ruminants has been an EU regulatory requirement since 2002. A number of European countries have subsequently reported cases of atypical scrapie, similar to previously published cases from Norway, which have pathological and molecular features distinct from classical scrapie. Most cases have occurred singly in flocks, associated with genotypes considered to be more resistant to classical disease. Experimental transmissibility of such isolates has been reported in certain ovinised transgenic mice, but has not previously been reported in the natural host. Information on the transmissibility of this agent is vital to ensuring that disease control measures are effective and proportionate.

Results

SUBMITTER: Simmons MM 

PROVIDER: S-EPMC2025597 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature