Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle.

ABSTRACT: Insulin resistance and type 2 diabetes are associated with decreased expression of genes that regulate oxidative phosphorylation in skeletal muscle. To determine whether this defect might be inherited or acquired, we investigated the association of genetic, epigenetic, and nongenetic factors with expression of NDUFB6, a component of the respiratory chain that is decreased in muscle from diabetic patients. Expression of NDUFB6 was influenced by age, with lower gene expression in muscle of elderly subjects. Heritability of NDUFB6 expression in muscle was estimated to be approximately 60% in twins. A polymorphism in the NDUFB6 promoter region that creates a possible DNA methylation site (rs629566, A/G) was associated with a decline in muscle NDUFB6 expression with age. Although young subjects

SUBMITTER: Ling C 

PROVIDER: S-EPMC2030455 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature