Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing.

ABSTRACT:

Background

Various typing methods have been developed for Neisseria gonorrhoeae, but none provide the combination of discrimination, reproducibility, portability, and genetic inference that allows the analysis of all aspects of the epidemiology of this pathogen from a single data set. Multilocus sequence typing (MLST) has been used successfully to characterize the related organisms Neisseria meningitidis and Neisseria lactamica. Here, the same seven locus Neisseria scheme was used to characterize a diverse collection of N. gonorrhoeae isolates to investigate whether this method would allow differentiation among isolates, and to distinguish these three species.

Results

A total of 149 gonococcal isolates were typed and submitted to the Neisseria MLST database. Although relativ

SUBMITTER: Bennett JS 

PROVIDER: S-EPMC2031879 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature