Genome wide expression analysis in HPV16 cervical cancer: identification of altered metabolic pathways.

ABSTRACT:

Background

Cervical carcinoma (CC) is a leading cause of death among women worldwide. Human papilloma virus (HPV) is a major etiological factor in CC and HPV 16 is the more frequent viral type present. Our aim was to characterize metabolic pathways altered in HPV 16 tumor samples by means of transcriptome wide analysis and bioinformatics tools for visualizing expression data in the context of KEGG biological pathways.

Results

We found 2,067 genes significantly up or down-modulated (at least 2-fold) in tumor clinical samples compared to normal tissues, representing ~3.7% of analyzed genes. Cervical carcinoma was associated with an important up-regulation of Wnt signaling pathway, which was validated by in situ hybridization in clinical samples. Other up-regulated pathways wer

SUBMITTER: Perez-Plasencia C 

PROVIDER: S-EPMC2034543 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature