Rapid diagnosis of pneumococcal pneumonia among HIV-infected adults with urine antigen detection.

ABSTRACT:

Objectives

Streptococcus pneumoniae is the leading cause of bacterial pneumonia and associated bacteremia during HIV infection. Rapid diagnostic assays may limit inappropriate therapy.

Methods

Clinical signs and symptoms and sera and urine were collected prospectively from 70 adults with pneumococcal pneumonia, including 47 with HIV co-infection. Pneumococcal C-polysaccharide antigen was detected in urine using the Binax immunochromatographic test (ICT). A systematic review of 24 published studies was conducted.

Results

Clinical symptoms, signs, and laboratory parameters except leukocytosis, were similar in HIV-infected and HIV-seronegative pneumonia. The performance of the urine antigen ICT was independent of HIV-status (sensitivity 81%, specificity 98%, positive (PP

SUBMITTER: Boulware DR 

PROVIDER: S-EPMC2039755 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature