Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss).

ABSTRACT:

Background

Fast, efficiently growing animals have increased protein synthesis and/or reduced protein degradation relative to slow, inefficiently growing animals. Consequently, minimizing the energetic cost of protein turnover is a strategic goal for enhancing animal growth. Characterization of gene expression profiles associated with protein turnover would allow us to identify genes that could potentially be used as molecular biomarkers to select for germplasm with improved protein accretion.

Results

We evaluated changes in hepatic global gene expression in response to 3-week starvation in rainbow trout (Oncorhynchus mykiss). Microarray analysis revealed a coordinated, down-regulated expression of protein biosynthesis genes in starved fish. In addition, the expression of gen

SUBMITTER: Salem M 

PROVIDER: S-EPMC2040161 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature