Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1.

ABSTRACT:

Background

Experimental data accumulated over more than a decade indicate that cross-strain protection against influenza may be achieved by immunization with conserved influenza proteins. At the same time, the efficacy of immunization schemes designed along these lines and involving internal influenza proteins, mostly NP and M1, has not been sufficient.

Objective

To test the immunogenicity and protective efficacy of DNA vaccination with a combination of NP, M1 and NS1 genes of influenza virus.

Methods

The immunogenicity and protective efficacy of DNA vaccination with NP, M1 and NS1 was tested in mice and chickens. Mice were challenged with mouse-adapted viral strains H3N2 and H5N2 and chicken challenged with avian H5N3 virus.

Results

In these settings, wild-typ

SUBMITTER: Zhirnov OP 

PROVIDER: S-EPMC2040185 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature