Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder.

ABSTRACT:

Background

The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD).

Methods

We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands with early-onset OCD. Best estimate lifetime psychiatric diagnoses were based on semistructured interviews and all other available sources of information. Parametric and nonparametric linkage analyses were conducted with GENEHUNTER+ and Allegro. Family-based association analyses were done using 35 single nucleotide polymorphisms (SNPs) in the 10p15 region.

Results

The maximum nonparametric log of odds (NLOD) score was 2.43 on chromosome 10p15 at position

SUBMITTER: Hanna GL 

PROVIDER: S-EPMC2040499 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature