Inflammatory basis of exercise-induced bronchoconstriction.

ABSTRACT:

Rationale

Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition.

Objectives

Our goals were to establish whether epithelial cell and mast cell activation with release of inflammatory mediators occurs during EIB and how histamine and cysteinyl leukotriene antagonists alter the airway events occurring during EIB.

Methods

Induced sputum was used to measure mast cell mediators and eicosanoids at baseline and 30 minutes after exercise challenge in 25 individuals with asthma with EIB. In a randomized, double-blind crossover study, the cysteinyl leukotriene antagonist montelukast and antihistamine loratadine or two matched

SUBMITTER: Hallstrand TS 

PROVIDER: S-EPMC2041799 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature