The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite.

ABSTRACT:

Background

An enhanced understanding of the hookworm genome and its resident mobile genetic elements should facilitate understanding of the genome evolution, genome organization, possibly host-parasite co-evolution and horizontal gene transfer, and from a practical perspective, development of transposon-based transgenesis for hookworms and other parasitic nematodes.

Methodology/principal findings

A novel mariner-like element (MLE) was characterized from the genome of the dog hookworm, Ancylostoma caninum, and termed bandit. The consensus sequence of the bandit transposon was 1,285 base pairs (bp) in length. The new transposon was flanked by perfect terminal inverted repeats of 32 nucleotides in length with a common target site duplication TA, and it encoded an open reading f

SUBMITTER: Laha T 

PROVIDER: S-EPMC2041818 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature