Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells.

ABSTRACT: Exposure of adult humans to manganese (Mn) has long been known to cause neurotoxicity. Recent evidence also suggests that exposure of children to Mn is associated with developmental neurotoxicity. Astrocytes are critical for the proper functioning of the nervous system, and they play active roles in neurogenesis, synaptogenesis and synaptic neurotransmission. In this report, to help elucidate the molecular events underlying Mn neurotoxicity, we systematically identified the molecular targets of Mn in primary human astrocytes at a genome-wide level, by using microarray gene expression profiling and computational data analysis algorithms. We found that Mn altered the expression of diverse genes ranging from those encoding cytokines and transporters to signal transducers and transcriptional r

SUBMITTER: Sengupta A 

PROVIDER: S-EPMC2041834 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature