Apo and calcium-bound crystal structures of Alpha-11 giardin, an unusual annexin from Giardia lamblia.

ABSTRACT: Alpha-11 giardin is a member of the multi-gene alpha-giardin family in the intestinal protozoan, Giardia lamblia. This gene family shares an ancestry with the annexin super family, whose common characteristic is calcium-dependent binding to membranes that contain acidic phospholipids. Several alpha giardins are highly expressed during parasite-induced diarrhea in humans. Despite being a member of a large family of proteins, little is known about the function and cellular localization of alpha-11 giardin, although giardins are often associated with the cytoskeleton. It has been shown that Giardia exhibits high levels of alpha-11 giardin mRNA transcript throughout its life cycle; however, constitutive over-expression of this protein is lethal to the parasite. Determining the three-dimensiona

SUBMITTER: Pathuri P 

PROVIDER: S-EPMC2041935 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature