Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers.

ABSTRACT:

Background

Drug addiction is associated with significant disease and death, but its impact on the ageing process has not been considered. The recent demonstration that many of the items available in routine clinical pathology have applicability as biomarkers of the ageing process implies that routine clinical laboratory parameters would be useful as an initial investigation of this possibility.

Methods

12,093 clinical laboratory results 1995-2006 were reviewed. To make the age ranges of the medical and addicted groups comparable the age range was restricted to 15-45 years.

Results

739 drug addicted (DA) and 5834 general medical (GM) age matched blood samples were compared. Significant elevation of immune parameters was noted in the C-reactive protein, erythrocyte sedi

SUBMITTER: Reece AS 

PROVIDER: S-EPMC2041948 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature