Ontology highlight
ABSTRACT:
SUBMITTER: Gironella M
PROVIDER: S-EPMC2042180 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Gironella Meritxell M Seux Mylène M Xie Min-Jue MJ Cano Carla C Tomasini Richard R Gommeaux Julien J Garcia Stephane S Nowak Jonathan J Yeung Man Lung ML Jeang Kuan-Teh KT Chaix Amandine A Fazli Ladan L Motoo Yoshiharu Y Wang Qing Q Rocchi Palma P Russo Antonio A Gleave Martin M Dagorn Jean-Charles JC Iovanna Juan L JL Carrier Alice A Pébusque Marie-Josèphe MJ Dusetti Nelson J NJ
Proceedings of the National Academy of Sciences of the United States of America 20071002 41
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s ...[more]