Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.

ABSTRACT: A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global microarray and proteomic analyses revealed that 167 transcripts and 73 proteins changed expression with the conserved RNA-binding protein Hfq identified as a likely global regulator involved in the response to this environment. Hfq involvement was confirmed with a ground-based microgravity culture mod

SUBMITTER: Wilson JW 

PROVIDER: S-EPMC2042201 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature