What's new in using platelet research? To unravel thrombopathies and other human disorders.

ABSTRACT: This review on platelet research focuses on defects of adhesion, cytoskeletal organisation, signal transduction and secretion. Platelet defects can be studied by different laboratory platelet functional assays and morphological studies. Easy bruising or a suspected platelet-based bleeding disorder is of course the most obvious reason to test the platelet function in a patient. However, nowadays platelet research also contributes to our understanding of human pathology in other disciplines such as neurology, nephrology, endocrinology and metabolic diseases. Apart from a discussion on classical thrombopathies, this review will also deal with the less commonly known relation between platelet research and disorders with a broader clinical phenotype. Classical thrombopathies involve disorders o

SUBMITTER: Freson K 

PROVIDER: S-EPMC2042511 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature