Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

ABSTRACT: Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.

SUBMITTER: Peng LF 

PROVIDER: S-EPMC2043288 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature