Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.

ABSTRACT: The correct morphology and migration of neurons, which is essential for the normal development of the nervous system, is enabled by the regulation of their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific F-actin-binding protein, has an essential function in the developing forebrain. We show that gain and loss of Neurabin-I expression affect neuronal morphology, neurite outgrowth, and radial migration of differentiating cortical and hippocampal neurons, suggesting that tight regulation of Neurabin-I function is required for normal forebrain development. Importantly, loss of Neurabin-I prevents pyramidal neurons from migrating into the cerebral cortex, indicating its essential role during early stages of corticogenesis. We demonstrate that in neurons Rac1 activation is

SUBMITTER: Causeret F 

PROVIDER: S-EPMC2043560 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature