An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data.

ABSTRACT:

Background

Protein-protein interactions (PPIs) are challenging but attractive targets for small chemical drugs. Whole PPIs, called the 'interactome', have been emerged in several organisms, including human, based on the recent development of high-throughput screening (HTS) technologies. Individual PPIs have been targeted by small drug-like chemicals (SDCs), however, interactome data have not been fully utilized for exploring drug targets due to the lack of comprehensive methodology for utilizing these data. Here we propose an integrative in silico approach for discovering candidates for drug-targetable PPIs in interactome data.

Results

Our novel in silico screening system comprises three independent assessment procedures: i) detection of protein domains responsible for PPIs,

SUBMITTER: Sugaya N 

PROVIDER: S-EPMC2045083 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature