Evaluation of replication and pathogenicity of avian influenza a H7 subtype viruses in a mouse model.

ABSTRACT: Avian influenza A H7 subtype viruses pose a significant threat to human health because of their ability to transmit directly from domestic poultry to humans and to cause disease and, sometimes, death. Although it is important to develop vaccines against viruses of this subtype, very limited information is available on the immune response and pathogenesis of H7 viruses in animal models such as mice and ferrets. Ten H7 viruses were selected for possible vaccine development on the basis of their phylogenetic relationships and geographical locations. The virulence of the 10 viruses for mice and the immunogenicity of the viruses in mice and ferrets were evaluated to study the extent of antigenic relatedness and the level of cross-reactivity of antibodies. Most of the viruses showed similar patt

SUBMITTER: Joseph T 

PROVIDER: S-EPMC2045456 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature