Genetic and phenotypic variation of foot-and-mouth disease virus during serial passages in a natural host.

ABSTRACT: Foot-and-mouth disease virus (FMDV), like other RNA viruses, exhibits high mutation rates during replication that have been suggested to be of adaptive value. However, even though genetic variation in RNA viruses and, more specifically, FMDV has been extensively examined during virus replication in a wide variety of in vitro cell cultures, very little is known regarding the generation and effects of genetic variability of virus replication in the natural host under experimental conditions and no genetic data are available regarding the effects of serial passage in natural hosts. Here, we present the results of 20 serial contact transmissions of the highly pathogenic, pig-adapted O Taiwan 97 (O Tw97) isolate of FMDV in swine. We examined the virus genomic consensus sequences for a total of

SUBMITTER: Carrillo C 

PROVIDER: S-EPMC2045514 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature