Transfusion-related acute lung injury in the critically ill: prospective nested case-control study.

ABSTRACT:

Rationale

Acute lung injury (ALI) that develops 6 hours after transfusion (TRALI) is the leading cause of transfusion-related mortality. Several transfusion characteristics have been postulated as risk factors for TRALI, but the evidence is limited to retrospective studies.

Objectives

To compare patient and transfusion risk factors between patients who do and do not develop ALI.

Methods

In this prospective cohort study, consecutive transfused critically ill patients were closely observed for development of ALI. Donor samples were collected from the transfusion bags. Risk factors were compared between patients who developed ALI after transfusion and transfused control patients, matched by age, sex, and admission diagnosis.

Measurements and main results

Seventy-f

SUBMITTER: Gajic O 

PROVIDER: S-EPMC2048675 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature