Comprehensive testing of positionally cloned asthma genes in two populations.

ABSTRACT:

Rationale

Replication of gene-disease associations has become a requirement in complex trait genetics.

Objectives

In studies of childhood asthma from two different ethnic groups, we attempted to replicate associations with five potential asthma susceptibility genes previously identified by positional cloning.

Methods

We analyzed two family-based samples ascertained through an asthmatic proband: 497 European-American children from the Childhood Asthma Management Program and 439 Hispanic children from the Central Valley of Costa Rica. We genotyped 98 linkage disequilibrium-tagging single-nucleotide polymorphisms (SNPs) in five genes: ADAM33, DPP10, GPR154 (HUGO name: NPSR1), HLA-G, and the PHF11 locus (includes genes SETDB2 and RCBTB1). SNPs were tested for association

SUBMITTER: Hersh CP 

PROVIDER: S-EPMC2048676 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature