Genetic determinants of emphysema distribution in the national emphysema treatment trial.

ABSTRACT:

Rationale

Computed tomography (CT) scanning of the lung may reduce phenotypic heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and allow identification of genetic determinants of emphysema severity and distribution.

Objectives

We sought to identify genes associated with CT scan distribution of emphysema in individuals without alpha1-antitrypsin deficiency but with severe COPD.

Methods

We evaluated baseline CT densitometry phenotypes in 282 individuals with emphysema enrolled in the Genetics Ancillary Study of the National Emphysema Treatment Trial, and used regression models to identify genetic variants associated with emphysema distribution.

Measurements and main results

Emphysema distribution was assessed by two methods--a

SUBMITTER: DeMeo DL 

PROVIDER: S-EPMC2049064 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature