Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription.

ABSTRACT: Transcriptional control plays a key role in regulating epidermal proliferation and differentiation. Although ample information has been obtained on how epidermal homeostasis is controlled in adult skin, less is known about the control of proliferation/differentiation of epidermal stem/progenitor cells in the developing embryo. Ovol1, encoding a zinc finger protein homologous to Drosophila melanogaster Ovo, is expressed in embryonic epidermal progenitor cells that are transiting from proliferation to terminal differentiation. In this study, we demonstrate a function for Ovol1 in interfollicular epidermal development. In its absence, developing epidermis fails to properly restrict the proliferative potential of progenitor cells, and cultured keratinocytes fail to efficiently undergo growth a

SUBMITTER: Nair M 

PROVIDER: S-EPMC2063816 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature