Ontology highlight
ABSTRACT:
SUBMITTER: Woodward AM
PROVIDER: S-EPMC2063885 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Woodward Anna M AM Göhler Thomas T Luciani M Gloria MG Oehlmann Maren M Ge Xinquan X Gartner Anton A Jackson Dean A DA Blow J Julian JJ
The Journal of cell biology 20060601 5
In late mitosis and early G1, replication origins are licensed for subsequent use by loading complexes of the minichromosome maintenance proteins 2-7 (Mcm2-7). The number of Mcm2-7 complexes loaded onto DNA greatly exceeds the number of replication origins used during S phase, but the function of the excess Mcm2-7 is unknown. Using Xenopus laevis egg extracts, we show that these excess Mcm2-7 complexes license additional dormant origins that do not fire during unperturbed S phases because of sup ...[more]