Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood.

ABSTRACT: COUP-TF-interacting protein 2 (CTIP2), also known as Bcl11b, is a transcriptional regulatory protein that is highly expressed in and plays a critical role(s) during development of T lymphocytes and the central nervous system. We demonstrate herein that CTIP2 is also highly expressed in mouse skin during embryogenesis and in adulthood as revealed by immunohistochemical analyses. CTIP2 expression in the ectoderm was first detected at embryonic day 10.5 (E10.5), and became increasingly restricted to proliferating cells of the basal cell layer of the developing epidermis in later stages of fetal development and in adult skin. In addition, CTIP2 expression was also detected in some cells of the suprabasal layer of the developing epidermis, as well as in developing and mature hair follicles. Rel

SUBMITTER: Golonzhka O 

PROVIDER: S-EPMC2063996 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature