Ontology highlight
ABSTRACT:
SUBMITTER: Sachs BD
PROVIDER: S-EPMC2064370 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
The Journal of cell biology 20070601 6
Clearance of fibrin through proteolytic degradation is a critical step of matrix remodeling that contributes to tissue repair in a variety of pathological conditions, such as stroke, atherosclerosis, and pulmonary disease. However, the molecular mechanisms that regulate fibrin deposition are not known. Here, we report that the p75 neurotrophin receptor (p75(NTR)), a TNF receptor superfamily member up-regulated after tissue injury, blocks fibrinolysis by down-regulating the serine protease, tissu ...[more]