Rare exonic minisatellite alleles in MUC2 influence susceptibility to gastric carcinoma.

ABSTRACT:

Background

Mucins are the major components of mucus and their genes share a common, centrally-located region of sequence that encodes tandem repeats. Mucins are well known genes with respect to their specific expression levels; however, their genomic levels are unclear because of complex genomic properties. In this study, we identified eight novel minisatellites from the entire MUC2 region and investigated how allelic variation in these minisatellites may affect susceptibility to gastrointestinal cancer.

Methodology/principle findings

We analyzed genomic DNA from the blood of normal healthy individuals and multi-generational family groups. Six of the eight minisatellites exhibited polymorphism and were transmitted meiotically in seven families, following Mendelian inheritanc

SUBMITTER: Jeong YH 

PROVIDER: S-EPMC2065792 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature