Common human cancer genes discovered by integrated gene-expression analysis.

ABSTRACT:

Background

Microarray technology enables a standardized, objective assessment of oncological diagnosis and prognosis. However, such studies are typically specific to certain cancer types, and the results have limited use due to inadequate validation in large patient cohorts. Discovery of genes commonly regulated in cancer may have an important implication in understanding the common molecular mechanism of cancer.

Methods and findings

We described an integrated gene-expression analysis of 2,186 samples from 39 studies to identify and validate a cancer type-independent gene signature that can identify cancer patients for a wide variety of human malignancies. The commonness of gene expression in 20 types of common cancer was assessed in 20 training datasets. The discriminative

SUBMITTER: Lu Y 

PROVIDER: S-EPMC2065803 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature