Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension.

ABSTRACT:

Background

As part of the NHLBI Family Blood Pressure Program, the Genetic Epidemiology Network of Arteriopathy (GENOA) recruited 575 sibships (n = 1583 individuals) from Rochester, MN who had at least two hypertensive siblings diagnosed before age 60. Linkage analysis identified a region on chromosome 2 that was investigated using 70 single nucleotide polymorphisms (SNPs) typed in 7 positional candidate genes, including adducin 2 (ADD2).

Method

To investigate whether blood pressure (BP) levels in these hypertensives (n = 1133) were influenced by gene-by-drug interactions, we used cross-validation statistical methods (i.e., estimating a model for predicting BP levels in one subgroup and testing it in a different subgroup). These methods greatly reduced the chance of false po

SUBMITTER: Kardia SL 

PROVIDER: S-EPMC2065870 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature