Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression.

ABSTRACT: Nuclear receptors (NRs) are transcription factors that are implicated in several biological processes such as embryonic development, homeostasis, and metabolic diseases. To study the role of NRs in development, it is critically important to know when and where individual genes are expressed. Although systematic expression studies using reverse transcriptase PCR and/or DNA microarrays have been performed in classical model systems such as Drosophila and mouse, no systematic atlas describing NR involvement during embryonic development on a global scale has been assembled. Adopting a systems biology approach, we conducted a systematic analysis of the dynamic spatiotemporal expression of all NR genes as well as their main transcriptional coregulators during zebrafish development (101 genes) us

SUBMITTER: Bertrand S 

PROVIDER: S-EPMC2065881 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature