Identification of a novel modulator of thyroid hormone receptor-mediated action.

ABSTRACT:

Background

Diabetes is characterized by reduced thyroid function and altered myogenesis after muscle injury. Here we identify a novel component of thyroid hormone action that is repressed in diabetic rat muscle.

Methodology/principal findings

We have identified a gene, named DOR, abundantly expressed in insulin-sensitive tissues such as skeletal muscle and heart, whose expression is highly repressed in muscle from obese diabetic rats. DOR expression is up-regulated during muscle differentiation and its loss-of-function has a negative impact on gene expression programmes linked to myogenesis or driven by thyroid hormones. In agreement with this, DOR enhances the transcriptional activity of the thyroid hormone receptor TR(alpha1). This function is driven by the N-terminal part

SUBMITTER: Baumgartner BG 

PROVIDER: S-EPMC2065906 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature