Ontology highlight
ABSTRACT:
SUBMITTER: Gasse P
PROVIDER: S-EPMC2066195 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Gasse Pamela P Mary Caroline C Guenon Isabelle I Noulin Nicolas N Charron Sabine S Schnyder-Candrian Silvia S Schnyder Bruno B Akira Shizuo S Quesniaux Valérie F J VF Lagente Vincent V Ryffel Bernhard B Couillin Isabelle I
The Journal of clinical investigation 20071201 12
The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1 receptor 1 (IL-1R1) and the common adaptor for Toll/IL-1R signal transduction, MyD88, in this process using a murine model of acute pulmonary injury. Bleomycin insult results in expression of neutrophil and lymphocyte chemotactic factors, chronic inflammation, remodeling, and fibrosis. We demonstrate that these end points were attenuated in the ...[more]