Adaptation and response of Bifidobacterium animalis subsp. lactis to bile: a proteomic and physiological approach.

ABSTRACT: Bile salts are natural detergents that facilitate the digestion and absorption of the hydrophobic components of the diet. However, their amphiphilic nature makes them very inhibitory for bacteria and strongly influences bacterial survival in the gastrointestinal tract. Adaptation to and tolerance of bile stress is therefore crucial for the persistence of bacteria in the human colonic niche. Bifidobacterium animalis subsp. lactis, a probiotic bacterium with documented health benefits, is applied largely in fermented dairy products. In this study, the effect of bile salts on proteomes of B. animalis subsp. lactis IPLA 4549 and its bile-resistant derivative B. animalis subsp. lactis 4549dOx was analyzed, leading to the identification of proteins which may represent the targets of bile salt re

SUBMITTER: Sanchez B 

PROVIDER: S-EPMC2074956 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature