Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils.

ABSTRACT:

Background

Polymorphonuclear neutrophils (PMN) constitute an essential cellular component of innate host defense against microbial invasion and exhibit a wide array of responses both to particulate and soluble stimuli. As the cells recruited earliest during acute inflammation, PMN respond rapidly and release a variety of potent cytotoxic agents within minutes of exposure to microbes or their products. PMN rely on the redistribution of functionally important proteins, from intracellular compartments to the plasma membrane and phagosome, as the means by which to respond quickly. To determine the range of membrane proteins available for rapid recruitment during PMN activation, we analyzed the proteins in subcellular fractions enriched for plasma membrane and secretory vesicles recover

SUBMITTER: Jethwaney D 

PROVIDER: S-EPMC2075486 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature