Genome-wide analyses of human perisylvian cerebral cortical patterning.

ABSTRACT: Despite the well established role of the frontal and posterior perisylvian cortices in many facets of human-cognitive specializations, including language, little is known about the developmental patterning of these regions in the human brain. We performed a genome-wide analysis of human cerebral patterning during midgestation, a critical epoch in cortical regionalization. A total of 345 genes were identified as differentially expressed between superior temporal gyrus (STG) and the remaining cerebral cortex. Gene ontology categories representing transcription factors were enriched in STG, whereas cell-adhesion and extracellular matrix molecules were enriched in the other cortical regions. Quantitative RT-PCR or in situ hybridization was performed to validate differential expression in a sub

SUBMITTER: Abrahams BS 

PROVIDER: S-EPMC2077018 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature