Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer.

ABSTRACT:

Background

Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic power and the underlying biological pathways of different gene signatures.

Methods

Gene signatures to predict the development of metastases in estrogen receptor-positive and estrogen receptor-negative tumors were identified using 500 re-sampled training sets and mapping to Gene Ontology Biological Process to identify over-represented pathways. The Global Test program confirmed that gene expression profilings in the common pathways were associated with the metastasis of the patients.

Results

The apoptotic pathway and cell division, or cell growth regulation and G-protein coupled receptor signal transducti

SUBMITTER: Yu JX 

PROVIDER: S-EPMC2077336 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature