Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton.

ABSTRACT:

Background

The actin cytoskeleton plays a crucial role in supporting and regulating numerous cellular processes. Mutations or alterations in the expression levels affecting the actin cytoskeleton system or related regulatory mechanisms are often associated with complex diseases such as cancer. Understanding how qualitative or quantitative changes in expression of the set of actin cytoskeleton genes are integrated to control actin dynamics and organisation is currently a challenge and should provide insights in identifying potential targets for drug discovery. Here we report the development of a dedicated microarray, the Actichip, containing 60-mer oligonucleotide probes for 327 genes selected for transcriptome analysis of the human actin cytoskeleton.

Results

Genomic data an

SUBMITTER: Muller J 

PROVIDER: S-EPMC2077341 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature