Protein kinase Cgamma autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer.

ABSTRACT:

Background

The clinical and immunological profiles of patients with paraneoplastic cerebellar degeneration (PCD) and non-small-cell lung cancer (NSCLC) are not well known.

Objective

To review the clinical and immunological features of patients with PCD, NSCLC and without well-characterised onconeural antibodies.

Methods

The clinical features of nine patients with the diagnosis of classical PCD and NSCLC, included in our archives, were retrospectively reviewed. The presence of antibodies to cerebellar components was determined by immunohistochemistry and immunoblot of rat cerebellum. A cDNA library of human cerebellum was screened with the positive sera to identify the antigen.

Results

Nine patients with PCD and NSCLC were identified. Six patients were men, and

SUBMITTER: Sabater L 

PROVIDER: S-EPMC2077410 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature