Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies.

ABSTRACT:

Background

Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection.

Methods

We present the first two reports of post-streptococcal OM associated with antibodies against a 56 kDa protein. Two young girls presented with opsoclonus and myoclonus following a febrile illness and pharyngitis. Protein purification techniques were employed. Amino acid sequences of human neuroleukin (NLK) and streptococcal proteins were compared using the protein-protein BLAST application.

Results

The antigen was identified as NLK (glucose-6-phosphate isomerase, GPI). GPI is present on the cell surface of streptococcus making the protein a c

SUBMITTER: Candler PM 

PROVIDER: S-EPMC2077526 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature