Inflammation-related genes up-regulated in schizophrenia brains.

ABSTRACT:

Background

Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by medication is a challenging task. The main goal of this study is to find transcriptional alterations in schizophrenia that are independent of neuroleptic treatment.

Methods

We compared the transcriptional profiles in brain autopsy samples from 55 control individuals with that from 55 schizophrenic subjects, subdivided according to the type of antipsychotic medication received.

Results

Using global and high-resolution mRNA quantification techniques, we show that genes involved in immune response (GO:0006955) are up regulated in all groups of patients, including those not treated at the

SUBMITTER: Saetre P 

PROVIDER: S-EPMC2080573 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature