Differential gene expression between Mycobacterium bovis and Mycobacterium tuberculosis.

ABSTRACT: The high sequence identity among the Mycobacterium bovis and Mycobacterium tuberculosis genomes contrasts with the physiological differences reported between these pathogens, suggesting that variations in gene expression may be involved. In this study, microarray hybridization was used to compare the total transcriptome of M. bovis and M. tuberculosis, during the exponential phase of growth. Differential expression was detected in 258 genes, representing a 6% of the total genome. Variable genes were grouped according to functional categories. The main variations were found in genes encoding proteins involved in intermediary metabolism and respiration, cell wall processes, and hypothetical proteins. It is noteworthy that, compared to M. tuberculosis, the expression of a higher number of tra

SUBMITTER: Rehren G 

PROVIDER: S-EPMC2080781 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature